Mounjaro (tirzepatide) affects digestion, appetite regulation, hydration, and multiple organ systems. While many patients experience mild gastrointestinal symptoms, others develop severe or long-lasting side effectsrequiring hospitalization, surgery, or long-term care.
This page outlines Mounjaro side effects in detail, from common reactions to serious complications, and explains when symptoms may indicate a medical emergency.
Why Mounjaro Causes Side Effects
By activating both GLP-1 and GIP receptors, Mounjaro:
- slows gastric emptying
- suppresses appetite
- alters intestinal motility
- affects fluid balance
- changes vascular regulation
In some patients, these effects become excessive or pathological.
Common Mounjaro Side Effects
Frequently reported effects include:
- nausea
- vomiting
- diarrhea
- constipation
- abdominal pain
- bloating
- decreased appetite
- fatigue
- dizziness
Symptoms often appear during dose increases but may persist.
Severe Gastrointestinal Side Effects
Persistent Vomiting & Inability to Eat
Some patients experience:
- daily vomiting
- inability to tolerate food or fluids
- dehydration
- repeated ER visits
Vomiting lasting more than a few days is not normal.
Motility Disorders & Bowel Shutdown
Mounjaro has been associated with:
- gastroparesis
- ileus
- severe constipation
- generalized GI dysmotility
➡️ Related: Motility Disorders
Kidney-Related Side Effects
Ongoing GI symptoms can lead to:
- dehydration
- acute kidney injury
- worsening kidney disease
- dialysis in severe cases
Warning signs include minimal urination and dark urine.
➡️ Related: Dehydration and Kidney Damage
Gallbladder Side Effects
Rapid weight loss may increase the risk of:
- gallstones
- gallbladder attacks
- gallbladder inflammation
- gallbladder removal surgery
➡️ Related: Gallbladder Removal
Pancreatitis Risk
Symptoms may include:
- severe upper abdominal pain
- pain radiating to the back
- vomiting
- hospitalization
Pancreatitis can be recurrent and dangerous.
➡️ Related: Pancreatitis
Vision Side Effects & Blindness (NAION)
Serious vision problems reported include:
- sudden vision loss
- blurred or dim vision
- loss of peripheral vision
- NAION
NAION can cause permanent blindness, often without warning.
➡️ Related:
Long-Term & Persistent Side Effects
Some patients report symptoms that:
- continue months after stopping
- require permanent dietary changes
- interfere with work and daily life
- result in chronic disability
➡️ Related: Permanent Injuries
When to Seek Immediate Medical Care
Get urgent help if you experience:
- vomiting lasting more than 48–72 hours
- inability to eat or drink
- severe abdominal pain or swelling
- no bowel movement for several days
- minimal urine output
- sudden vision changes
Mounjaro Side Effects and Lawsuits
Mounjaro side effects are central to GLP-1 litigation, particularly cases involving:
- severe motility disorders
- kidney injury
- gallbladder surgery
- pancreatitis
- blindness / NAION
➡️ Mounjaro lawsuits: Lawsuits
Mounjaro can cause a wide range of side effects, from mild nausea to severe, permanent, and life-altering injuries. Because of its dual-hormone action, some patients experience particularly intense or persistent complications.
If you experienced serious side effects after using Mounjaro, medical and legal review may be appropriate.
➡️ Start your review: File a Claim